Muscle relaxants are medications decreasing skeletal muscles tone with reduction of motion activity to full immobilization.
The muscle relaxant started its history in 16th century when the South-American Indians are revealed to use for hunting and war the poisoned arrows, poison was curare leading to death because of respiratory muscles paralysis. After investigations of this poison the scientists have found out a great effect of anesthesia that leads to surgery development. This helped to study the mechanism of neuromuscular transmission. Since 1943 the nervously-muscular blockers have known in medicine as muscle relaxants.